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Get Epi-Informatics: Discovery and Development of Small Molecule PDF

By Jose Medina-Franco

ISBN-10: 0128028084

ISBN-13: 9780128028087

Epi-Informatics: Discovery and improvement of Small Molecule Epigenetic medicinal drugs and Probes positive aspects multidisciplinary options with powerful computational ways that experience ended in the profitable discovery and/or optimization of compounds that act as modulators of epigenetic ambitions. This ebook is meant for all these utilizing or eager to examine extra approximately computational methodologies in epigenetic drug discovery, together with molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists.

With a greater figuring out of alternative molecular modeling and cheminformatic ways, readers can comprise those recommendations into their very own drug discovery tasks which can contain chemical synthesis and medium- or high-throughput screening. furthermore, this publication highlights the importance of epigenetic objectives to the general public future health for molecular modelers and chemoinformatians. The objective of this reference is to stimulate ongoing multidisciplinary study and to extra increase present computational methodologies and workflows which will speed up the invention and improvement of epi-drugs and epi-probes.

  • Focuses at the discovery of epi-drugs as applicants for use in treatment together with mixed therapies
  • Describes new computational methodologies and screening assays using fresh and rising novel structural data
  • Highlights the invention, improvement and optimization of epi-probes, that are molecular probes that elucidate epigenetic mechanisms
  • Includes very important issues equivalent to computational-guided optimization of epi-hits, digital screening to spot novel compounds for epigenetic ambitions, improvement and mining of epigenetic molecular databases, SAR modeling of screening information and masses more

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Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes by Jose Medina-Franco

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